Cochrane PEARLS: antidepresivos y tabaquismo

Which antidepressants are effective in aiding long term smoking cessation?

Bottom line: Both bupropion and nortriptyline double the odds of cessation when compared to placebo (median NNT* = 11 and 10respectively). The efficacy of bupropion and nortriptyline appears to be similar to that for nicotine replacement and is not restricted to people with a history of depression or depressive symptoms during smoking abstinence. Selective serotonin reuptake inhibitors (SSRIs),venlafaxine and moclobemide show no evidence of benefit.* NNT = number needed to treat to benefitone individual.

Caveat: Bupropion can cause insomnia, dry mouth, nausea and seizures (estimated risk = 1 in1000). Nortriptyline can cause dry mouth, constipation, nausea and sedation, and can be dangerous in overdose.

Context: Smoking is the most preventable cause of premature death, accounting for about17% of all deaths in developed countries.

Cochrane PEARLS Practical Evidence About Real Life Situations. No. 18, September 2007
Bupropion and nortriptyline aid long term smoking cessation but selective serotonin reuptake inhibitors do not.
Brian R McAvoy Published by the Cochrane Primary Care Group.
Posted on Global Family Doctor 30 October, 2007